Dorsomorphin
Catalog Number : 8666430
description
Dorsomorphin is a potent and selective inhibitor of the BMP pathway through the ALK2, ALK3, and ALK6 receptors. It is also a selective and reversible inhibitor of the AMP-activated protein kinase (AMPK). Dorsomorphin is reported to be useful in promoting specific cell differentiation and inducing cancer cell line autophagy.
Additional Information
Applications: | FA |
Synonyms: | Compound C, AMPK Inhibitor, BML-275 |
Formulation: | Crystalline solid |
Chemical Name: | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine |
Molecular Formula: | C24H25N5O |
Molecular Weight: | 399.5 |
CAS Number | 866405-64-3 |
Purity: | ≥98% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Paul, B. Y., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., ... & Peterson, R. T. (2008). Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature chemical biology, 4(1), 33-41. Hao, J., Daleo, M. A., Murphy, C. K., Yu, P. B., Ho, J. N., Hu, J., ... & Hong, C. C. (2008). Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PloS one, 3(8), e2904. Boergermann, J. H., Kopf, J., Yu, P. B., & Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry & cell biology, 42(11), 1802-1807. |