DMOG
Catalog Number : 8946314
description
DMOG is a cell permeable Prolyl 4-hydroxylase (P4H) inhibitor which activates the hypoxia-inducible factor (HIF) in cultured cells. DMOG is reported to delay neuronal cell death caused by trophic factor deprivation through a HIF-1 alpha-independent, glucose-dependent mechanism.
Additional Information
Applications:
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FA
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Synonyms:
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Dimethyloxallyl glycine, dimethyloxalylglycine, methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
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Formulation:
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Crystalline solid
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Chemical Name:
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methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetat
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Molecular Formula:
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C6H9NO5 |
Molecular Weight: |
175.1
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CAS Number
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89464-63-1
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Hill, P., Shukla, D., Tran, M. G., Aragones, J., Cook, H. T., Carmeliet, P., & Maxwell, P. H. (2008). Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. Journal of the American Society of Nephrology, 19(1), 39-46. Milkiewicz, M., Pugh, C. W., & Egginton, S. (2004). Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.The Journal of physiology, 560(1), 21-26. Sears, J. E., Hoppe, G., Ebrahem, Q., & Anand-Apte, B. (2008). Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy.Proceedings of the National Academy of Sciences, 105(50), 19898-19903. |