Dibutyryl-cAMP, sodium salt
Catalog Number : 1698950
description
Dibutyryl-cAMP is a cell-permeable activator of cAMP-dependent protein kinases and phosphodiesterase inhibitor. It mimics endogenous cyclic adenosine monophosphate (cAMP). Dibutyryl-cAMP is reported to induce apoptosis in vascular smooth muscle cells and induce neurite growth.
Additional Information
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Applications:
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FA
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Synonyms:
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Bucladesine sodium salt, Actosin, MLS001148197
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Formulation:
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Crystalline solid
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Chemical Name:
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sodium;[(4aR,6R,7R,7aR)-6-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate
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Molecular Formula:
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C18H23N5O8P Na |
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Molecular Weight: |
491.4
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CAS Number
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16980-89-5
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Kahn, A. M., Dolson, G. M., Hise, M. K., Bennett, S. C., & Weinman, E. J. (1985). Parathyroid hormone and dibutyryl cAMP inhibit Na+/H+ exchange in renal brush border vesicles. American Journal of Physiology-Renal Physiology, 248(2), F212-F218. Leonard, J. L. (1988). Dibutyryl cAMP induction of type II 5′ deiodinase activity in rat brain astrocytes in culture. Biochemical and biophysical research communications, 151(3), 1164-1172. Rundfeldt, C., Steckel, H., Sörensen, T., & Wlaz, P. (2012). The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Archives of dermatological research, 304(4), 313-317. |