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Daunorubicin hydrochloride



Catalog Number : 2355061

Description

Daunorubicin hydrochloride is a RNA and DNA synthesis inhibitor that functions in part by blocking the function of topoisomerase II. It is reported to induce apoptosis in acute myeloid leukemia (AML) cells. It is currently being researched as a potential treatment for COVID-19.
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Additional Information

Applications:
FA
Synonyms:
Dauno Rubidomycine, Cerubidine, Daunoblastine, Daunorubicin, Rubidomycin, NSC 82151
Formulation:
Crystalline solid
Chemical Name:
(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
Molecular Formula:

C27H29NO10 HCl

Molecular Weight:
564.0
CAS Number
23541-50-6
Purity:
98%
Storage Conditions:
Product should be kept at -20°C.
References:

Jaffrezou, J. P., Levade, T., Bettaieb, A., Andrieu, N., Bezombes, C., Maestre, N., ... & Laurent, G. (1996). Daunorubicin‐induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. The EMBO journal15(10), 2417-2424.

Slater, L. M., Murray, S. L., Wetzel, M. W., Wisdom, R. M., & Duvall, E. M. (1982). Verapamil restoration of daunorubicin responsiveness in daunorubicin-resistant Ehrlich ascites carcinoma. The Journal of clinical investigation70(5), 1131-1134.

Farag, A., Wang, P., Ahmed, M., & Sadek, H. (2020). Identification of FDA Approved Drugs Targeting COVID-19 Virus by Structure-Based Drug Repositioning.


Availability: In stock

Size Price Qty
10mg
$90.00
100mg
$540.00