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DAPT



Catalog Number : 2088055

Description

DAPT is a potent inhibitor of the gamma-secretase complex, which is an internal protease that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. DAPT also indirectly inhibits the Notch protein. It is reported promote neuronal differentiation and enhance the apoptosis of human tongue carcinoma cells.
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Additional Information

Applications:
FA
Synonyms:
gamma-Secretase Inhibitor IX, GSI IX, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine tert-butyl ester
Formulation:
Crystalline solid
Chemical Name:
tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
Molecular Formula:

C23H26F2N2O4

Molecular Weight:
432.5
CAS Number
208255-80-5
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

El Mouedden, M., Vandermeeren, M., Meert, T., & Mercken, M. (2005). Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors. Current pharmaceutical design12(6), 671-676.

Yagishita, S., Morishima-Kawashima, M., Tanimura, Y., Ishiura, S., & Ihara, Y. (2006). DAPT-induced intracellular accumulations of longer amyloid β-proteins: further implications for the mechanism of intramembrane cleavage by γ-secretase. Biochemistry45(12), 3952-3960.

Crawford, T. Q., & Roelink, H. (2007). The Notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell‐derived embryoid bodies independently of sonic hedgehog signaling. Developmental Dynamics,236(3), 886-892.

Grottkau, B. E., Friedrich, C. C., Jing, W., & Wu, Y. (2009). DAPT enhances the apoptosis of human tongue carcinoma cells. International journal of oral science1(2), 81-89.


Availability: In stock

Size Price Qty
10mg
$150.00
50mg
$620.00