CUR-61414
Catalog Number : 3343668
description
CUR-61414 is a potent antagonist of SMO (smoothened) in the hedgehog signaling pathway. Smoothened can function as an oncogene and CUR-61414 is reported to block proliferation and induce apoptosis in cancer cells.
Additional Information
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Applications:
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FA
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Synonyms:
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CUR 61414, CUR61414, G-024586
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Formulation:
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Crystalline solid
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Chemical Name:
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N-[1-(1,3-benzodioxol-5-ylmethyl)-5-(piperazine-1-carbonyl)pyrrolidin-3-yl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
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Molecular Formula:
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C31H42N4O5 |
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Molecular Weight: |
550.7
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CAS Number
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334998-36-6
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Williams, J. A. (2003). Hedgehog signaling pathway as a target for therapeutic intervention in basal cell carcinoma. Drug News Perspect,16(10), 657-662. Rubin, L. L., & de Sauvage, F. J. (2006). Targeting the Hedgehog pathway in cancer. Nature reviews Drug discovery, 5(12), 1026-1033. Stanton, B. Z., & Peng, L. F. (2010). Small-molecule modulators of the Sonic Hedgehog signaling pathway. Molecular BioSystems, 6(1), 44-54. |