Clozapine N-oxide
Catalog Number : 3426973
description
Clozapine N-oxide is a normally biologically inactive metabolite of clozapine that can be used to specifically activate DREAD receptors, engineered G-protein coupled receptors which are activated by otherwise inert drug-like small molecules. Clozapine is metabolized in the liver by the cytochrome P450 system and is a partial agonist of the serotonin receptor.
Additional Information
|
Applications:
|
FA
|
|
Synonyms:
|
Clozapine (N-oxide), MZA8BK588J, N-Oxyclozapine
|
|
Formulation:
|
Crystalline solid
|
|
Chemical Name:
|
3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine
|
|
Molecular Formula:
|
C18H19ClN4O |
|
Molecular Weight: |
342.8
|
|
CAS Number
|
34233-69-7
|
|
Purity:
|
≥98%
|
|
Storage Conditions:
|
Product should be kept at -20°C.
|
|
References:
|
Volpicelli, S. A., Centorrino, F., Puopolo, P. R., Kando, J., Frankenburg, F. R., Baldessarini, R. J., & Flood, J. G. (1993). Determination of clozapine, norclozapine, and clozapine-N-oxide in serum by liquid chromatography.Clinical chemistry, 39(8), 1656-1659. Jann, M. W., Lam, Y. W., & Chang, W. H. (1993). Rapid formation of clozapine in guinea-pigs and man following clozapine-N-oxide administration.Archives internationales de pharmacodynamie et de therapie, 328(2), 243-250. Farrell, M. S., Pei, Y., Wan, Y., Yadav, P. N., Daigle, T. L., Urban, D. J., ... & Huang, X. P. (2013). A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology,38(5), 854-862. |