CHR 2797
Catalog Number : 2387710
description
CHR 2797 is an antiproliferative aminopeptidase inhibitor, also known as tosedostat. Inside cells, it is converted into a pharmacologically active acid product, CHR-79888. It is reported that CHR 2797 deplete sensitive tumor cells of amino acids by blocking protein recycling to generate an antiproliferative effect.
Additional Information
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Applications:
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FA
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Synonyms:
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Tosedostat, CHR-2797, CHR2797
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Formulation:
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Crystalline solid
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Chemical Name:
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cyclopentyl (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-2-phenylacetate
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Molecular Formula:
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C21H30N2O6 |
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Molecular Weight: |
406.5
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CAS Number
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238750-77-1
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Purity:
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98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Krige, D., Needham, L. A., Bawden, L. J., Flores, N., Farmer, H., Miles, L. E., ... & Kirwin-Jones, P. (2008). CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer research, 68(16), 6669-6679. Jenkins, C., Hewamana, S., Krige, D., Pepper, C., & Burnett, A. (2011). Aminopeptidase inhibition by the novel agent CHR-2797 (tosedostat) for the therapy of acute myeloid leukemia. Leukemia research, 35(5), 677-681. Anbalagan, S., Biasoli, D., Leszczynska, K. B., Mukherjee, S., & Hammond, E. M. (2015). In vitro radiosensitization of esophageal cancer cells with the aminopeptidase inhibitor CHR-2797. Radiation research, 184(3), 259-265. |