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CHR 2797



Catalog Number : 2387710

Description

CHR 2797 is an antiproliferative aminopeptidase inhibitor, also known as tosedostat. Inside cells, it is converted into a pharmacologically active acid product, CHR-79888. It is reported that CHR 2797 deplete sensitive tumor cells of amino acids by blocking protein recycling to generate an antiproliferative effect.
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Additional Information

Applications:
FA
Synonyms:
Tosedostat, CHR-2797, CHR2797
Formulation:
Crystalline solid
Chemical Name:
cyclopentyl (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-2-phenylacetate
Molecular Formula:

C21H30N2O6

Molecular Weight:
406.5
CAS Number
238750-77-1
Purity:
98%
Storage Conditions:
Product should be kept at -20°C.
References:

Krige, D., Needham, L. A., Bawden, L. J., Flores, N., Farmer, H., Miles, L. E., ... & Kirwin-Jones, P. (2008). CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer research68(16), 6669-6679.

Jenkins, C., Hewamana, S., Krige, D., Pepper, C., & Burnett, A. (2011). Aminopeptidase inhibition by the novel agent CHR-2797 (tosedostat) for the therapy of acute myeloid leukemia. Leukemia research35(5), 677-681.

Anbalagan, S., Biasoli, D., Leszczynska, K. B., Mukherjee, S., & Hammond, E. M. (2015). In vitro radiosensitization of esophageal cancer cells with the aminopeptidase inhibitor CHR-2797. Radiation research184(3), 259-265.


Availability: In stock

Size Price Qty
1mg
$85.00
5mg
$380.00