Cdk4 Inhibitor
Catalog Number : 5466072
description
Cdk4 Inhibitor is an indolocarbazole and potent inhibitor of cyclin D1/Cdk4. It induces G1 cell cycles arrest and inhibits the pRb phosphorylation in HCT-116 and NCI-H460 cells.
Additional Information
Applications:
|
FA
|
Synonyms:
|
Cyclin-dependent kinase 4 Inhibitor
|
Formulation:
|
Crystalline solid
|
Chemical Name:
|
6-bromo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaene-12,14-dione
|
Molecular Formula:
|
C20H10BrN3O2
|
Molecular Weight: |
404.2
|
CAS Number
|
546102-60-7
|
Purity:
|
≥90%
|
Storage Conditions:
|
Product should be kept at -20°C.
|
References:
|
Zhu, G., Conner, S. E., Zhou, X., Shih, C., Li, T., Anderson, B. D., ... & Faul, M. M. (2003). Synthesis, structure− activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. Journal of medicinal chemistry, 46(11), 2027-2030.
Sun, Y., Li, Y. X., Wu, H. J., Wu, S. H., Wang, Y. A., Luo, D. Z., & Liao, D. J. (2011). Effects of an indolocarbazole-derived CDK4 inhibitor on breast cancer cells. Journal of Cancer, 2, 36.
|