Creating Value for Life Science Research!


Get a Free Sample of this product!
shopping cart image

Carfilzomib



Catalog Number : 8681740

Description

Carfilzomib is a selective irreversible proteasome inhibitor and analog of epoxomicin. It binds to and inhibits the chymotrypsin-like activity of the 20S proteasome. Carfilzomib is reported to inhibit tumor growth and induce cell cycle arrest and apoptosis.
product image

Additional Information

Applications:
FA
Synonyms:
Kyprolis, PR-171
Formulation:
Crystalline solid
Chemical Name:
(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide
Molecular Formula:

C40H57N5O7

Molecular Weight:
719.9
CAS Number
868540-17-4
Purity:
98%
Storage Conditions:
Product should be kept at -20°C.
References:
Kortuem, K. M., & Stewart, A. K. (2013). Carfilzomib. Blood, The Journal of the American Society of Hematology, 121(6), 893-897. Yang, J., Wang, Z., Fang, Y., Jiang, J., Zhao, F., Wong, H., ... & Kirk, C. J. (2011). Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats. Drug Metabolism and Disposition, 39(10), 1873-1882. Stewart, A. K., Rajkumar, S. V., Dimopoulos, M. A., Masszi, T., Špička, I., Oriol, A., ... & Goranova-Marinova, V. (2015). Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. New England Journal of Medicine, 372(2), 142-152.

Availability: In stock

Size Price Qty
5mg
$210.00
50mg
$740.00