Brefeldin A
Catalog Number : 2031560
description
Brefeldin A is a lactone antibiotic originating discovered in fungi capable of inhibiting protein transport from the endolasmic reticulum to the Golgi apparatus. It is reported to act on the guanine nucleotide exchange factor named GBF1 that mediates the formation of transport vesicles and the unfolded protein response can result in apoptosis in some cells.
Additional Information
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Applications:
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FA
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Synonyms:
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Ascotoxin, Cyanein, Decumbin, Synergisidin
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Formulation:
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Crystalline solid
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Chemical Name:
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(1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one
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Molecular Formula:
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C16H24O4 |
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Molecular Weight: |
280.4
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CAS Number
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20350-15-6
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Misumi, Y., Miki, K., Takatsuki, A., Tamura, G., & Ikehara, Y. (1986). Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes. Journal of Biological Chemistry, 261(24), 11398-11403. Lippincott-Schwartz, J., Yuan, L. C., Bonifacino, J. S., & Klausner, R. D. (1989). Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell, 56(5), 801-813. Fujiwara, T., Oda, K., Yokota, S., Takatsuki, A., & Ikehara, Y. (1988). Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum. Journal of Biological Chemistry, 263(34), 18545-18552. |