BrdU
Catalog Number : 5911439
description
BrdU is a synthetic nucleoside that is an analog of thymidine and is commonly used in the detection of proliferating cells in living tissues. It is reported that BrdU can be used to promote chemical induction of mouse iPSCSs in conjunction with other chemical reagents including, CHIR 99021, ALK5 Inhibitor (RepSox), and Forskolin. BrdU is also reported to induce a sustained reduction in the proliferation rate of cancer cells.
Additional Information
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Applications:
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FA
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Synonyms:
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Bromodeoxyuridine, Broxuridine, 5-Bromo-2'-deoxyuridine, 5-BrdU, 5-Bromouracil deoxyriboside, 5-Bromo-2-deoxyuridine
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Formulation:
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Crystalline solid
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Chemical Name:
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5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
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Molecular Formula:
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C9H11BrN2O5 |
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Molecular Weight: |
307.1
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CAS Number
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59-14-3
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Taupin, P. (2007). BrdU immunohistochemistry for studying adult neurogenesis: paradigms, pitfalls, limitations, and validation. Brain research reviews, 53(1), 198-214. Long, Y., Wang, M., Gu, H., & Xie, X. (2015). Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells. Cell research. Levkoff, L. H., Marshall, G. P., Ross, H. H., Caldeira, M., Reynolds, B. A., Cakiroglu, M., ... & Laywell, E. D. (2008). Bromodeoxyuridine inhibits cancer cell proliferation in vitro and in vivo. Neoplasia, 10(8), 804-IN13. |