Bictegravir
Catalog Number : 1616073
description
Bictegravir is a potent inhibitor of HIV-1 integrase. The HIV integrase plays a pivotal role in the insertion of the reverse-transcribed viral genome into the genome of the host cell. Bictegravir exhibits antiviral activity without the requirement of pharmacokinetic boosting.
Additional Information
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Applications:
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FA
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Synonyms:
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GS-9883, GS9883, SB18851
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Formulation:
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Crystalline solid
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Chemical Name:
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(1S,11R,13R)-5-hydroxy-3,6-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-12-oxa-2,9-diazatetracyclo[11.2.1.02,11.04,9]hexadeca-4,7-diene-7-carboxamide
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Molecular Formula:
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C21H18F3N3O5 |
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Molecular Weight: |
449.4
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CAS Number
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1611493-60-7
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Purity:
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98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Tsiang, M., Jones, G. S., Goldsmith, J., Mulato, A., Hansen, D., Kan, E., ... & Niedziela-Majka, A. (2016). Antiviral activity of bictegravir (GS-9883), a novel potent HIV-1 integrase strand transfer inhibitor with an improved resistance profile. Antimicrobial agents and chemotherapy, 60(12), 7086-7097. Zhang, H., Custodio, J., Wei, X., Wang, H., Wu, A., Ling, J., ... & Kearney, B. (2017). P176 Clinical pharmacology of the HIV integrase strand transfer inhibitor bictegravir. Sex Transm Infect, 93(Suppl 1), A74-A74. Deeks, E. D. (2018). Bictegravir/emtricitabine/tenofovir alafenamide: a review in HIV-1 infection. Drugs, 78(17), 1817-1828. |