Bictegravir
Catalog Number : 1616073
description
Bictegravir is a potent inhibitor of HIV-1 integrase. The HIV integrase plays a pivotal role in the insertion of the reverse-transcribed viral genome into the genome of the host cell. Bictegravir exhibits antiviral activity without the requirement of pharmacokinetic boosting.
Additional Information
Applications: | FA |
Synonyms: | GS-9883, GS9883, SB18851 |
Formulation: | Crystalline solid |
Chemical Name: | (1S,11R,13R)-5-hydroxy-3,6-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-12-oxa-2,9-diazatetracyclo[11.2.1.02,11.04,9]hexadeca-4,7-diene-7-carboxamide |
Molecular Formula: | C21H18F3N3O5 |
Molecular Weight: | 449.4 |
CAS Number | 1611493-60-7 |
Purity: | 98% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Tsiang, M., Jones, G. S., Goldsmith, J., Mulato, A., Hansen, D., Kan, E., ... & Niedziela-Majka, A. (2016). Antiviral activity of bictegravir (GS-9883), a novel potent HIV-1 integrase strand transfer inhibitor with an improved resistance profile. Antimicrobial agents and chemotherapy, 60(12), 7086-7097. Zhang, H., Custodio, J., Wei, X., Wang, H., Wu, A., Ling, J., ... & Kearney, B. (2017). P176 Clinical pharmacology of the HIV integrase strand transfer inhibitor bictegravir. Sex Transm Infect, 93(Suppl 1), A74-A74. Deeks, E. D. (2018). Bictegravir/emtricitabine/tenofovir alafenamide: a review in HIV-1 infection. Drugs, 78(17), 1817-1828. |