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Bictegravir



Catalog Number : 1616073

Description

Bictegravir is a potent inhibitor of HIV-1 integrase. The HIV integrase plays a pivotal role in the insertion of the reverse-transcribed viral genome into the genome of the host cell. Bictegravir exhibits antiviral activity without the requirement of pharmacokinetic boosting.
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Additional Information

Applications:
FA
Synonyms:
GS-9883, GS9883, SB18851
Formulation:
Crystalline solid
Chemical Name:
(1S,11R,13R)-5-hydroxy-3,6-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-12-oxa-2,9-diazatetracyclo[11.2.1.02,11.04,9]hexadeca-4,7-diene-7-carboxamide
Molecular Formula:

C21H18F3N3O5

Molecular Weight:
449.4
CAS Number
1611493-60-7
Purity:
98%
Storage Conditions:
Product should be kept at -20°C.
References:

Tsiang, M., Jones, G. S., Goldsmith, J., Mulato, A., Hansen, D., Kan, E., ... & Niedziela-Majka, A. (2016). Antiviral activity of bictegravir (GS-9883), a novel potent HIV-1 integrase strand transfer inhibitor with an improved resistance profile. Antimicrobial agents and chemotherapy60(12), 7086-7097.

Zhang, H., Custodio, J., Wei, X., Wang, H., Wu, A., Ling, J., ... & Kearney, B. (2017). P176 Clinical pharmacology of the HIV integrase strand transfer inhibitor bictegravir. Sex Transm Infect93(Suppl 1), A74-A74.

Deeks, E. D. (2018). Bictegravir/emtricitabine/tenofovir alafenamide: a review in HIV-1 infection. Drugs78(17), 1817-1828.


Availability: In stock

Size Price Qty
1mg
$120.00
10mg
$870.00