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Anti-Rat CD8b SAFIRE Purified



Catalog Number : 10113-25

Description

The 341 monoclonal antibody specifically reacts with the beta chain of the Rat CD8 molecule. The alpha and beta chains of the CD8 molecule form a heterodimer common on most thymocytes. The CD8 positive T cells of athymic rats and most NK cells express a homodimer composed solely of CD8a. It is reported that macrophages express CD8 alpha and beta chains for signal transduction. CD8 is an antigen co-receptor that interacts with MHC class I molecules on antigen-presenting cells.

Additional Information

Clone:
341
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Rat
Isotype:
Mouse IgG1, kappa
Research Interest: Adaptive Immunity
Cell Type: NK and NKT Cells, T Cells
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Hirji, N., Lin, T. J., Bissonnette, E., Belosevic, M., & Befus, A. D. (1998). Mechanisms of macrophage stimulation through CD8: macrophage CD8α and CD8β induce nitric oxide production and associated killing of the parasite Leishmania major. The Journal of Immunology160(12), 6004-6011.

Hirji, N., Lin, T. J., & Befus, A. D. (1997). A novel CD8 molecule expressed by alveolar and peritoneal macrophages stimulates nitric oxide production. The Journal of Immunology158(4), 1833-1840.

Torres‐Nagel, N., Kraus, E., Brown, M. H., Tiefenthaler, G., Mitnacht, R., Williams, A. F., & Hünig, T. (1992). Differential thymus dependence of rat CD8 isoform expression. European journal of immunology22(11), 2841-2848.


Availability: In stock

Size Price Qty
500 ug
$310.00
Additional 341 Formats
Cat.No. Format Starting From
10113-25SAFIRE Purified $ 310.00