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Anti-Rat CD3 SAFIRE Purified



Catalog Number : 05113-25

Description

The G4.18 monoclonal antibody specifically reacts with rat CD3, a T cell lineage marker and associated with the T cell receptor (TCR). CD3 is involved in antigen recognition, cell activation, and signal transduction and is found on subsets of NK-T, peripheral T, dendritic epidermal T, and thymocyte cells. Immobilized G4.18 antibody activates T cells in vitro and in vivo treatments of the G4.18 antibody prevents cardiac and skin allograft rejection.

Additional Information

Clone:
G4.18
Format:
SAFIRE Purified
Applications:
FC, IHC, FA
Reactivity:
Rat
Isotype:
Mouse IgG3, kappa
Research Interest: Adaptive Immunity
Cell Type: NK and NKT Cells
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Nicolls, M. R., Aversa, G. G., Pearce, N. W., Spinelli, A., Berger, M. F., Gurley, K. E., & Hall, B. M. (1993). Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody.Transplantation55(3), 459-468.

Morris, D. L., & Komocsar, W. J. (1997). Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats.Journal of pharmacological and toxicological methods37(1), 37-46.

Tran, G. T., Carter, N., He, X. Y., Spicer, T. S., Plain, K. M., Nicolls, M., ... & Hodgkinson, S. J. (2001). Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on Th1 cells that is augmented by IL-4. International immunology13(9), 1109-1120.


Availability: In stock

Size Price Qty
500 ug
$350.00
Additional G4.18 Formats
Cat.No. Format Starting From
05113-50FITC $ 80.00
05113-25SAFIRE Purified $ 350.00
05113-60PE $ 90.00