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Anti-Mouse TLR4/MD-2 Complex SAFIRE Purified

Catalog Number : 74812-25


The MTS510 monoclonal antibody specifically reacts with the Toll-Like Receptor 4 (TLR-4) and MD-2 (LY96) molecular complex. The complex of TLR-4, MD-2, and CD14 regulates the innate immune system recognition of bacterial lipopolysaccharides (LPS) and is expressed on the surface of thioglycollate-elicited macrophages. The epitope that binds the MTS510 antibody is lost after LPS stimulation and the antibody can be used to co-immunoprecipitates MD-2 and TLR4.

Additional Information

SAFIRE Purified
Rat IgG2a, kappa
Research Interest: Innate Immunity
Cell Type: Monocytes and Macrophages, T Cells, Dendritic Cells
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Phosphate-buffered aqueous solution, ph7.2.

Akashi, S., Saitoh, S. I., Wakabayashi, Y., Kikuchi, T., Takamura, N., Nagai, Y., ... & Miyake, K. (2003). Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2 Higher Affinity than That with MD-2 or CD14. The Journal of experimental medicine198(7), 1035-1042.

Qi, H. Y., & Shelhamer, J. H. (2005). Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages. Journal of Biological Chemistry,280(47), 38969-38975.

Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., & Kimoto, M. (1999). MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. The Journal of experimental medicine,189(11), 1777-1782.

Availability: In stock

Size Price Qty
50 ug
100 ug
Additional MTS510 Formats
Cat.No. Format Starting From
74812-25SAFIRE Purified $ 200.00