Anti-Mouse/Rat TNF-alpha SAFIRE Purified
Additional TN3-19 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 84412-25 | SAFIRE Purified | $ 525.00 |
Catalog Number : 84412-25
description
The TN3-19 monoclonal antibody reacts with mouse and rat tumor-necrosis (TNF) alpha proteins. It is not cross-reactive with mouse TNF-Beta or human TNF. TNF-Alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. The TN3-19 antibody is reported to be a neutralizing antibody.
Additional Information
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Clone:
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TN3-19
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Format:
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SAFIRE Purified
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Applications:
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FA
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Reactivity:
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Mouse, Rat
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Isotype:
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Armenian Hamster IgG
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| Research Interest: | Innate Immunity, Adaptive Immunity |
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| Cell Type: | Macrophage / Monocyte, NK and NKT Cells, T Cells |
| Application: | FA |
| Clone: | TN3-19 |
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Preparation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Williams, R. O., Feldmann, M., & Maini, R. N. (1992). Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proceedings of the National Academy of Sciences, 89(20), 9784-9788. Leiby, D. A., Fortier, A. H., Crawford, R. M., Schreiber, R. D., & Nacy, C. A. (1992). In vivo modulation of the murine immune response to Francisella tularensis LVS by administration of anticytokine antibodies. Infection and immunity, 60(1), 84-89. Sheehan, K. C., Ruddle, N. H., & Schreiber, R. D. (1989). Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors. The Journal of Immunology, 142(11), 3884-3893. |