Creating Value for Life Science Research!


Get a Free Sample of this product!
shopping cart image

Anti-Mouse/Rat IL-17A PE



Catalog Number : 73812-60

Description

The 17B7 monoclonal antibody specifically binds to mouse and rat IL-17A, a pro-inflammatory cytokine. It is produced by T helper 17 (Th17) cells, a unique subset of IL-23 dependent CD4+ T cells. Interleukin-17A is highly expressed in transplant rejection, asthma, psoriasis, and multiple sclerosis, and enhances the expression of ICAM-1 in human fibroblasts. The homodimer is expressed by activated peripheral CD4+ T lymphocytes. The Interleukin-17A binds to the IL-17 receptors (IL-17R) expressed by mast cells, monocytes and macrophages, fibroblasts, and endothelial and epithelial cells.

Additional Information

Clone:
17B7
Format:
PE
Applications:
FC
Reactivity:
Mouse, Rat
Isotype:
Rat IgG2a, kappa
Research Interest: Adaptive Immunity, Cytokines & Growth Factors
Cell Type: T Cells, Th17 cells
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Wu, S., Rhee, K. J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H. R., ... & Sears, C. L. (2009). A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nature medicine15(9), 1016-1022.

Cao, H., Lan, Q., Shi, Q., Zhou, X., Liu, G., Liu, J., ... & Liu, Z. (2011). Anti-IL-23 antibody blockade of IL-23/IL-17 pathway attenuates airway obliteration in rat orthotopic tracheal transplantation. International immunopharmacology11(5), 569-575.

Yan, S., Wang, L., Liu, N., Wang, Y., & Chu, Y. (2012). Critical role of interleukin-17/interleukin-17 receptor axis in mediating Con A-induced hepatitis.Immunology and cell biology90(4), 421-428.


Availability: In stock

Size Price Qty
50 ug
$180.00
Additional 17B7 Formats
Cat.No. Format Starting From
73812-50FITC $ 110.00
73812-60PE $ 180.00
73812-80APC $ 210.00