Anti-Mouse/Rat FOXP3 APC
Catalog Number : 83422-80
description
The FJK-16s monoclonal antibody specifically reacts with mouse and rat Foxp3, also known as Forkhead Box P3, Scurfin, IPEX, and JM2. The 49-55 kDA transcription factor is the primary marker for CD4+ CD25+ regulatory T cells. Treg cells suppress the cytokine production and proliferation of other T cells and are essential in T cell mediated autoimmunity. The FJK-16s antibody also cross reacts with porcine, dog, and cat.
Additional Information
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Clone:
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FJK-16s
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Format:
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APC
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Applications:
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FC
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Reactivity:
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Mouse, Rat
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Isotype:
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Rat IgG2a, kappa
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| Research Interest: | Adaptive Immunity |
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| Cell Type: | T Cells, T Regulatory Cells |
| Application: | FC |
| Clone: | FJK-16s |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Gerner, W., Stadler, M., Hammer, S. E., Klein, D., & Saalmüller, A. (2010). Sensitive detection of Foxp3 expression in bovine lymphocytes by flow cytometry. Veterinary immunology and immunopathology, 138(1-2), 154-158. Käser, T., Gerner, W., Hammer, S. E., Patzl, M., & Saalmüller, A. (2008). Detection of Foxp3 protein expression in porcine T lymphocytes. Veterinary immunology and immunopathology, 125(1-2), 92-101. Lankford, S., Petty, C., LaVoy, A., Reckling, S., Tompkins, W., & Dean, G. A. (2008). Cloning of feline FOXP3 and detection of expression in CD4+ CD25+ regulatory T cells. Veterinary immunology and immunopathology, 122(1-2), 159-166. |