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Anti-Mouse/Rat CD40 SAFIRE Purified



Catalog Number : 02512-25

Description

The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The HM40-3 antibody blocks the binding of CD40L (CD154) and stimulates B and dendritic cell proliferation.

Additional Information

Clone:
HM40-3
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Mouse, Rat
Isotype:
Armenian Hamster IgM, kappa
Research Interest: Adaptive Immunity
Cell Type: B Cells, Dendritic Cells, NK and NKT Cells, Monocytes and Macrophages
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Kaneko, Y., Hirose, S., Abe, M., Yagita, H., Okumura, K., & Shirai, T. (1996). CD40‐mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus. European journal of immunology26(12), 3061-3065.

Ferlin, W. G., Severinson, E., Ström, L., Heath, A. W., Coffman, R. L., Ferrick, D. A., & Howard, M. C. (1996). CD40 signaling induces interleukin‐4‐independent IgE switching in vivo. European journal of immunology26(12), 2911-2915.

Kashiwada, M., Kaneko, Y., Yagita, H., Okumura, K., & Takemori, T. (1996). Activation of mitogen‐activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells. European journal of immunology26(7), 1451-1458.


Availability: In stock

Size Price Qty
50 ug
$110.00
100 ug
$190.00
500 ug
$310.00
1 mg
$570.00
Additional HM40-3 Formats
Cat.No. Format Starting From
02512-50FITC $ 100.00
02512-25SAFIRE Purified $ 110.00