Anti-Mouse Perforin APC
Catalog Number : 84812-80
description
The OMAK-D monoclonal antibody reacts with mouse perforin, a 70kDA cytolytic protein also known as PFP, Cytolysin and PRF. It is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTL) and NK cells and used to mediate targeted cell lysis. The OMAK-D antibody is cross-reactive with human perforin.
Additional Information
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Clone:
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OMAK-D
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Format:
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APC
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Applications:
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FC
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Reactivity:
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Mouse
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Isotype:
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IgG2a, kappa
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| Research Interest: | Innate Immunity, Adaptive Immunity, Apoptosis |
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| Cell Type: | NK and NKT Cells, T Cells |
| Application: | FC |
| Clone: | OMAK-D |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Opferman, J. T., Ober, B. T., & Ashton-Rickardt, P. G. (1999). Linear differentiation of cytotoxic effectors into memory T lymphocytes. Science,283(5408), 1745-1748. Walsh, C. M., Matloubian, M., Liu, C. C., Ueda, R., Kurahara, C. G., Christensen, J. L., ... & Clark, W. R. (1994). Immune function in mice lacking the perforin gene. Proceedings of the National Academy of Sciences, 91(23), 10854-10858. Fehniger, T. A., Cai, S. F., Cao, X., Bredemeyer, A. J., Presti, R. M., French, A. R., & Ley, T. J. (2007). Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.Immunity, 26(6), 798-811. |