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Anti-Mouse Notch3 APC



Catalog Number : 73312-80

Description

The HMN3-133 monoclonal antibody specifically reacts with mouse Notch3, a single-pass transmembrane protein. After binding with its ligand, Notch3 receptor undergoes cleavage resulting in a Notch intracellular domain (NICD) molecule that eventually activates transcription in the nucleus. It is expressed on Treg cells and adult smooth muscle arterial cells.

Additional Information

Clone:
HMN3-133
Format:
APC
Applications:
FC
Reactivity:
Mouse
Isotype:
Armenian Hamster IgG
Research Interest: Stem Cell Research
Cell Type: T Cells, Treg cells, Stem Cells
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Moriyama, Y., Sekine, C., Koyanagi, A., Koyama, N., Ogata, H., Chiba, S., ... & Yagita, H. (2008). Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice. International immunology20(6), 763-773.

Bellavia, D., Checquolo, S., Campese, A. F., Felli, M. P., Gulino, A., & Screpanti, I. (2008). Notch3: from subtle structural differences to functional diversity. Oncogene27(38), 5092-5098.

Shi, J., Fallahi, M., Luo, J. L., & Petrie, H. T. (2011). Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis.Blood118(9), 2511-2519.


Availability: In stock

Size Price Qty
25 ug
$120.00
100 ug
$290.00
Additional HMN3-133 Formats
Cat.No. Format Starting From
73312-80APC $ 120.00