Anti-Mouse Notch3 APC
Catalog Number : 73312-80
description
The HMN3-133 monoclonal antibody specifically reacts with mouse Notch3, a single-pass transmembrane protein. After binding with its ligand, Notch3 receptor undergoes cleavage resulting in a Notch intracellular domain (NICD) molecule that eventually activates transcription in the nucleus. It is expressed on Treg cells and adult smooth muscle arterial cells.
Additional Information
Clone:
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HMN3-133
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Format:
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APC
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Applications:
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FC
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Reactivity:
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Mouse
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Isotype:
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Armenian Hamster IgG
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Research Interest: | Stem Cell Research |
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Cell Type: | T Cells, T Regulatory Cells, Stem Cells |
Application: | FC |
Clone: | HMN3-133 |
Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Moriyama, Y., Sekine, C., Koyanagi, A., Koyama, N., Ogata, H., Chiba, S., ... & Yagita, H. (2008). Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice. International immunology, 20(6), 763-773. Bellavia, D., Checquolo, S., Campese, A. F., Felli, M. P., Gulino, A., & Screpanti, I. (2008). Notch3: from subtle structural differences to functional diversity. Oncogene, 27(38), 5092-5098. Shi, J., Fallahi, M., Luo, J. L., & Petrie, H. T. (2011). Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis.Blood, 118(9), 2511-2519. |