Anti-Mouse IFN gamma SAFIRE Purified

Catalog Number : 80812-25

Description

The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-γ) protein, a 15 -17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-γ plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-α, to inhibit proliferation of normal and transformed cells. IFN- γ is the primary cytokine that defines Th-1 cells.

The biological activity of IFN-γ is not affected by glycosylation.

Additional Information

Clone	XMG1.2
Format:	SAFIRE Purified
Applications	FC, FA, IHC, IF, ELISA
Reactivity	Mouse
Isotype:	Rat IgG1, kappa
Research Interest:	Innate Immunity, Adaptive Immunity
Cell Type:	NK and NKT Cells, T Cells
Preperation:	The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:	Phosphate-buffered aqueous solution, ph7.2.
References:	Abrams, J. S., Roncarolo, M. G., Yssel, H., Andersson, U., Gleich, G. J., & Silver, J. E. (1992). Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunological reviews, 127(1), 5-24. Cherwinski, H. M., Schumacher, J. H., Brown, K. D., & Mosmann, T. R. (1987). Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. The Journal of experimental medicine, 166(5), 1229-1244. Zhang, Y., Xu, G., Zhang, L., Roberts, A. I., & Shi, Y. (2008). Th17 cells undergo Fas-mediated activation-induced cell death independent of IFN-γ. The Journal of Immunology, 181(1), 190-196.

Availability: In stock

Size	Price	Qty
100 μg	$150.00
500 μg	$225.00

Additional XMG1.2 Formats

Cat.No.	Format	Starting From
80812-60	PE	$ 65.00
80812-77	PE-Cyanine7	$ 110.00
80812-40	BG Violet 450	$ 95.00
80812-25	SAFIRE Purified	$ 150.00
80812-50	FITC	$ 55.00
80812-80	APC	$ 70.00
80812-30	Biotin	$ 70.00