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Anti-Mouse IFN gamma Biotin



Catalog Number : 80812-30

Description

The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-γ) protein, a 15 -17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-γ plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-α, to inhibit proliferation of normal and transformed cells. IFN- γ is the primary cytokine that defines Th-1 cells.

The biological activity of IFN-γ is not affected by glycosylation.

Additional Information

Clone:
XMG1.2
Format:
Biotin
Applications:
FC, ELISA
Reactivity:
Mouse
Isotype:
Rat IgG1, kappa
Research Interest: Adaptive Immunity, Innate Immunity
Cell Type: T Cells, NK and NKT Cells
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted biotin was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Abrams, J. S., Roncarolo, M. G., Yssel, H., Andersson, U., Gleich, G. J., & Silver, J. E. (1992). Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunological reviews127(1), 5-24.

Cherwinski, H. M., Schumacher, J. H., Brown, K. D., & Mosmann, T. R. (1987). Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. The Journal of experimental medicine166(5), 1229-1244.

Zhang, Y., Xu, G., Zhang, L., Roberts, A. I., & Shi, Y. (2008). Th17 cells undergo Fas-mediated activation-induced cell death independent of IFN-γ. The Journal of Immunology181(1), 190-196.


Availability: In stock

Size Price Qty
25 ug
$70.00
100 ug
$190.00
Additional XMG1.2 Formats
Cat.No. Format Starting From
80812-60PE $ 65.00
80812-77PE-Cyanine7 $ 110.00
80812-40BG Violet 450 $ 95.00
80812-25SAFIRE Purified $ 150.00
80812-50FITC $ 55.00
80812-80APC $ 70.00
80812-30Biotin $ 70.00