Anti-Mouse Fc epsilon Receptor I alpha (FceR1) SAFIRE Purified
description
The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.
The MAR-1 antibody is widely used both in flow cytometry and for depletion of cells in vitro / in vivo.
Additional Information
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Clone:
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MAR-1
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Format:
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SAFIRE Purified
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Applications:
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FC, FA, IHC, IP
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Reactivity:
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Mouse
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Isotype:
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Armenian Hamster IgG
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| Research Interest: | Innate Immunity |
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| Cell Type: | Macrophage / Monocyte |
| Application: | FC, FA, IHC, IP |
| Clone: | MAR-1 |
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Preparation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Joncker, N. T., Fernandez, N. C., Treiner, E., Vivier, E., & Raulet, D. H. (2009). NK cell responsiveness is tuned commensurate with the number of inhibitory receptors for self-MHC class I: the rheostat model. The Journal of Immunology,182(8), 4572-4580. Obata, K., Mukai, K., Tsujimura, Y., Ishiwata, K., Kawano, Y., Minegishi, Y., ... & Karasuyama, H. (2007). Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood, 110(3), 913-920. Arinobu, Y., Iwasaki, H., Gurish, M. F., Mizuno, S. I., Shigematsu, H., Ozawa, H., ... & Akashi, K. (2005). Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America, 102(50), 18105-18110. |