Anti-Mouse CD8a Purified
Additional 2.43 Formats
Cat.No. | Format | Starting From |
---|---|---|
10112-77 | PE-Cyanine7 | $ 80.00 |
10112-70 | PerCP-Cyanine5.5 | $ 110.00 |
10112-40 | BG Violet 450 | $ 95.00 |
10112-20 | Purified | $ 90.00 |
10112-60 | PE | $ 40.00 |
10112-50 | FITC | $ 30.00 |
10112-80 | APC | $ 70.00 |
description
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen. CD8a (the alpha chains) form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b.
CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells.
Additional Information
Clone:
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2.43
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Format:
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Purified
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Applications:
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FC, FA, IHC
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Reactivity:
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Mouse
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Isotype:
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Rat IgG2b
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Research Interest: | Adaptive Immunity |
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Cell Type: | NK and NKT Cells, T Cells |
Application: | FC, FA, IHC |
Clone: | 2.43 |
Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Salem, M. L., & Hossain, M. S. (2000). In vivo acute depletion of CD8+ T cells before murine cytomegalovirus infection upregulated innate antiviral activity of natural killer cells. International journal of immunopharmacology, 22(9), 707-718. Kruisbeek, A. M. (1991). In Vivo Depletion of CD4 and CD8 Specific T Cells.Current protocols in immunology, 4-1. Davies, A., Kalb, S., Liang, B., Aldrich, C. J., Lemonnier, F. A., Jiang, H., ... & Soloski, M. J. (2003). A peptide from heat shock protein 60 is the dominant peptide bound to Qa-1 in the absence of the MHC class Ia leader sequence peptide Qdm. The Journal of Immunology, 170(10), 5027-5033. |