Anti-Mouse CD70 SAFIRE Purified
Additional FR70 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 02812-25 | SAFIRE Purified | $ 170.00 |
Catalog Number : 02812-25
description
The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.
Additional Information
|
Clone:
|
FR70
|
|
Format:
|
SAFIRE Purified
|
|
Applications:
|
FC, FA
|
|
Reactivity:
|
Mouse
|
|
Isotype:
|
Rat IgG2b, kappa
|
| Research Interest: | Adaptive Immunity |
|---|---|
| Cell Type: | B Cells, T Cells, Dendritic Cells |
| Application: | FC, FA |
| Clone: | FR70 |
|
Preparation:
|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ph7.2.
|
|
References:
|
Tesselaar, K., Gravestein, L. A., Van Schijndel, G. M., Borst, J., & Van Lier, R. A. (1997). Characterization of murine CD70, the ligand of the TNF receptor family member CD27. The Journal of Immunology, 159(10), 4959-4965. Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., ... & Okumura, K. (1998). Characterization of murine CD70 by molecular cloning and mAb. International immunology, 10(4), 517-526. Bullock, T. N., & Yagita, H. (2005). Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells. The Journal of Immunology, 174(2), 710-717. |