Anti-mouse CD49d (Integrin alpha 4) SAFIRE Purified
Additional R1-2 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 11522-25 | SAFIRE Purified | $ 320.00 |
Catalog Number : 11522-25
description
The R1-2 monoclonal antibody specifically reacts with mouse CD49d (integrin alpha 4), which forms the VLA-4 complex with CD29 (integrin beta 1). VLA-4 is expressed on thymocytes, monocytes, and a subset of peripheral lymphocytes. It is the receptor for fibronectin and CD106 (VCAM-1). CD49d also forms a receptor for mucosal vascular addressin (MAdCAM-1) with integrin beta 7.
Additional Information
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Clone:
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R1-2
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Format:
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SAFIRE Purified
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Applications:
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FC, FA
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Reactivity:
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Mouse
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Isotype:
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Rat IgG2b, kappa
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| Research Interest: | Adaptive Immunity, Angiogenesis |
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| Cell Type: | T Cells, Macrophage / Monocyte, B Cells, Dendritic Cells |
| Application: | FC, FA |
| Clone: | R1-2 |
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Preparation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Baron, J. L., Reich, E. P., Visintin, I., & Janeway Jr, C. A. (1994). The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1. Journal of Clinical Investigation, 93(4), 1700. Chisholm, P. L., Williams, C. A., & Lobb, R. R. (1993). Monoclonal antibodies to the integrin α− 4 subunit inhibit the murine contact hypersensitivity response.European journal of immunology, 23(3), 682-688. Holzmann, B., McIntyre, B. W., & Weissman, I. L. (1989). Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α. Cell, 56(1), 37-46. |