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Anti-mouse CD49d (Integrin alpha 4) SAFIRE Purified



Catalog Number : 11522-25

Description

The R1-2 monoclonal antibody specifically reacts with mouse CD49d (integrin alpha 4), which forms the VLA-4 complex with CD29 (integrin beta 1). VLA-4 is expressed on thymocytes, monocytes, and a subset of peripheral lymphocytes. It is the receptor for fibronectin and CD106 (VCAM-1). CD49d also forms a receptor for mucosal vascular addressin (MAdCAM-1) with integrin beta 7.

Additional Information

Clone:
R1-2
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Mouse
Isotype:
Rat IgG2b, kappa
Research Interest: Adaptive Immunity, Angiogenesis
Cell Type: T Cells, Monocytes and Macrophages, B Cells, Dendritic Cells
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Baron, J. L., Reich, E. P., Visintin, I., & Janeway Jr, C. A. (1994). The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1. Journal of Clinical Investigation93(4), 1700.

Chisholm, P. L., Williams, C. A., & Lobb, R. R. (1993). Monoclonal antibodies to the integrin α− 4 subunit inhibit the murine contact hypersensitivity response.European journal of immunology23(3), 682-688.

Holzmann, B., McIntyre, B. W., & Weissman, I. L. (1989). Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α. Cell56(1), 37-46.


Availability: In stock

Size Price Qty
100 ug
$185.00
500 ug
$330.00
Additional R1-2 Formats
Cat.No. Format Starting From
11522-25SAFIRE Purified $ 185.00