Anti-Mouse CD3e PE-Cyanine5

Grouped product items
SizePrice Qty
25 μg
100 μg

Additional 145-2C11 Formats

Cat.No.FormatStarting From
05122-60PE$ 30.00
05122-65PE-Cyanine5$ 65.00
05122-70PerCP-Cyanine5.5 $ 70.00
05122-77PE-Cyanine7$ 70.00
05122-20Purified$ 65.00
05122-25SAFIRE Purified$ 105.00
05122-50FITC$ 25.00
05122-30Biotin$ 35.00
05122-80APC$ 55.00
Catalog Number : 05122-65


The 145-2C11 monoclonal antibody reacts with mouse CD3e, the 20 kDa ε chain of the TCR complex. Together with the γ and δ subunits of CD3, the ε subunits are involved in the assembly, trafficking, and surface expression of T-cell receptor complex. CD3 is expressed on thymocytes, mature T cells, and natural killer T cells, and the ε chain enhances the antigen recognition.

The 145-2C11 antibody binds to the TCR complex and, depending on the conditions, initiates T cells activation, proliferation, and apoptosis. The soluble antibody seems to block lysis of target cells by antigen-specific cytotoxic T lymphocytes.

The 145-2C11 antibody does not cross-react with the rat leukocytes, and it is used as a phenotypic marker for mouse T lymphocytes.

Additional Information

Armenian Hamster IgG
Research Interest:Adaptive Immunity
Cell Type:Th17 cells, NK and NKT Cells, T Cells, T Regulatory Cells
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Leo, O., Foo, M., Sachs, D. H., Samelson, L. E., & Bluestone, J. A. (1987). Identification of a monoclonal antibody specific for a murine T3 polypeptide.Proceedings of the National Academy of Sciences84(5), 1374-1378.

Nakano, H., Yamazaki, T., Miyatake, S., Nozaki, N., Kikuchi, A., & Saito, T. (1996). Specific Interaction of Topoisomerase II and the CD3 Chain of the T Cell Receptor Complex. Journal of Biological Chemistry271(11), 6483-6489.

Salmond, R. J., Filby, A., Pirinen, N., Magee, A. I., & Zamoyska, R. (2011). Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas. Blood117(1), 108-117.

© BioGems International, Inc. All rights reserved.