Anti-Mouse CD314 (NKG2D) PE
Catalog Number : 35312-60
description
The CX5 monoclonal antibody specifically binds to mouse CD314 (NKG2D), a transmembrane C-type lectin-like receptor. CD314 recognizes proteins that appear on the surface of infected, malignant, and transformed cells from MIC and RAET1/ULBP families. These CD314 ligands are absent or present at only low levels on the surface of normal cells. It serves as an activating receptor on NK cells and functions as a co-stimulatory signal on CD8 positive T cells. The CX5 antibody is reported to block the binding of ligands to the CD314 receptor.
Additional Information
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Clone:
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CX5
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Format:
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PE
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Applications:
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FC
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Reactivity:
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Mouse
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Isotype:
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Rat IgG1, kappa
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| Research Interest: | Innate Immunity |
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| Cell Type: | NK and NKT Cells |
| Application: | FC |
| Clone: | CX5 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Ogasawara, K., Benjamin, J., Takaki, R., Phillips, J. H., & Lanier, L. L. (2005). Function of NKG2D in natural killer cell–mediated rejection of mouse bone marrow grafts. Nature immunology, 6(9), 938-945. Cerwenka, A., Bakker, A. B., McClanahan, T., Wagner, J., Wu, J., Phillips, J. H., & Lanier, L. L. (2000). Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity, 12(6), 721-727. Diefenbach, A., Jamieson, A. M., Liu, S. D., Shastri, N., & Raulet, D. H. (2000). Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nature immunology, 1(2), 119-126. |