Anti-Mouse CD3 SAFIRE Purified
Additional 17A2 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 05112-87 | APC-Cyanine7 | $ 85.00 |
| 05112-40 | BG Violet 450 | $ 75.00 |
| 05112-20 | Purified | $ 20.00 |
| 05112-25 | SAFIRE Purified | $ 105.00 |
| 05112-60 | PE | $ 55.00 |
| 05112-80 | APC | $ 60.00 |
| 05112-50 | FITC | $ 25.00 |
description
The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains γ, δ, and ε subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex.
The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 ε chain.
Additional Information
Clone: | 17A2 |
Format: | SAFIRE Purified |
Applications: | FC, FA, IHC, IP |
Reactivity: | Mouse |
Isotype: | Rat IgG2b, kappa |
| Research Interest: | Adaptive Immunity |
|---|---|
| Cell Type: | Th17 cells, NK and NKT Cells, T Cells, T Regulatory Cells |
| Application: | FC, FA, IHC, IP |
| Clone: | 17A2 |
Preparation: | The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein. |
Formulation: | Phosphate-buffered aqueous solution, ph7.2. |
References: | Miescher, G. C., Schreyer, M., & MacDonald, H. R. (1989). Production and characterization of a rat monoclonal antibody against the murine CD3 molecular complex. Immunology letters, 23(2), 113-118. Mysliwietz, J., & Thierfelder, S. (1992). Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in the marrow recipient. Blood, 80(10), 2661-2667. Wu, L., Antica, M., Johnson, G. R., Scollay, R., & Shortman, K. (1991). Developmental potential of the earliest precursor cells from the adult mouse thymus. The Journal of experimental medicine, 174(6), 1617-1627. |