Anti-Mouse CD3 SAFIRE Purified

Grouped product items
Size Price Qty
100 μg
$105.00
500 μg
$180.00

Additional 17A2 Formats

Cat.No. Format Starting From
05112-87 APC-Cyanine7 $ 85.00
05112-40 BG Violet 450 $ 75.00
05112-20 Purified $ 20.00
05112-25 SAFIRE Purified $ 105.00
05112-60 PE $ 55.00
05112-80 APC $ 60.00
05112-50 FITC $ 25.00
Catalog Number : 05112-25

description

The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains γ, δ, and ε subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex.

The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 ε chain.

Additional Information

Clone:
17A2
Format:
SAFIRE Purified
Applications:
FC, FA, IHC, IP
Reactivity:
Mouse
Isotype:
Rat IgG2b, kappa
Research Interest: Adaptive Immunity
Cell Type: Th17 cells, NK and NKT Cells, T Cells, T Regulatory Cells
Application: FC, FA, IHC, IP
Clone: 17A2
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Miescher, G. C., Schreyer, M., & MacDonald, H. R. (1989). Production and characterization of a rat monoclonal antibody against the murine CD3 molecular complex. Immunology letters23(2), 113-118.

Mysliwietz, J., & Thierfelder, S. (1992). Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in the marrow recipient. Blood80(10), 2661-2667.

Wu, L., Antica, M., Johnson, G. R., Scollay, R., & Shortman, K. (1991). Developmental potential of the earliest precursor cells from the adult mouse thymus. The Journal of experimental medicine174(6), 1617-1627.

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