Anti-Mouse CD3 SAFIRE Purified

Catalog Number : 05112-25

Description

The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains γ, δ, and ε subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex.

The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 ε chain.

Additional Information

Clone:	17A2
Format:	SAFIRE Purified
Applications:	FC, FA, IHC, IP
Reactivity:	Mouse
Isotype:	Rat IgG2b, kappa
Research Interest:	Adaptive Immunity
Cell Type:	Th17 cells, NK and NKT Cells, T Cells, Treg cells
Preparation:	The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:	Phosphate-buffered aqueous solution, ph7.2.
References:	Miescher, G. C., Schreyer, M., & MacDonald, H. R. (1989). Production and characterization of a rat monoclonal antibody against the murine CD3 molecular complex. Immunology letters, 23(2), 113-118. Mysliwietz, J., & Thierfelder, S. (1992). Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in the marrow recipient. Blood, 80(10), 2661-2667. Wu, L., Antica, M., Johnson, G. R., Scollay, R., & Shortman, K. (1991). Developmental potential of the earliest precursor cells from the adult mouse thymus. The Journal of experimental medicine, 174(6), 1617-1627.

Availability: In stock

Size	Price	Qty
100 μg	$105.00
500 μg	$180.00

Additional 17A2 Formats

Cat.No.	Format	Starting From
05112-87	APC-Cyanine7	$ 85.00
05112-40	BG Violet 450	$ 75.00
05112-20	Purified	$ 20.00
05112-25	SAFIRE Purified	$ 105.00
05112-60	PE	$ 55.00
05112-80	APC	$ 60.00
05112-50	FITC	$ 25.00