Anti-Mouse CD223 (LAG-3) Purified
Rat IgG1, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||NK and NKT Cells, T Cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Li, N., Workman, C. J., Martin, S. M., & Vignali, D. A. (2004). Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223). The Journal of Immunology, 173(11), 6806-6812.
Cemerski, S., Zhao, S., Chenard, M., Laskey, J., Cui, L., Shukla, R., ... & Blumenschein, W. (2015). T cell activation and anti-tumor efficacy of anti-LAG-3 antibodies is independent of LAG-3-MHCII blocking capacity. Journal for immunotherapy of cancer, 3(Suppl 2).
Dawicki, W., Li, C., Town, J., Zhang, X., & Gordon, J. R. (2017). Therapeutic reversal of food allergen sensitivity by mature retinoic acid–differentiated dendritic cell induction of LAG3+ CD49b− Foxp3− regulatory T cells. Journal of Allergy and Clinical Immunology, 139(5), 1608-1620.