Anti-Mouse CD180 (RP-105) SAFIRE Purified
Catalog Number : 12912-25
description
The RP/14 monoclonal antibody binds to mouse CD180, a 105kDA cell surface molecule consisting of extracellular leucine rich repeats (LCC) and a short cytoplasmic tail also known as Bgp-95 and RP105. CD180 is expressed on B cells, dendritic cells, monocytes, and macrophages. It forms a cell surface receptor complex with MD-1 and with TLR4 is involved with the recognition of bacterial lipopolysaccharide (LPS).
Additional Information
Clone:
|
RP/14
|
Format:
|
SAFIRE Purified
|
Applications:
|
FC, FA
|
Reactivity:
|
Mouse
|
Isotype:
|
Rat IgG2a, kappa
|
Research Interest: | Innate Immunity, Apoptosis |
---|---|
Cell Type: | B Cells, Macrophage / Monocyte, Dendritic Cells |
Application: | FC, FA |
Clone: | RP/14 |
Preparation:
|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
|
Formulation:
|
Phosphate-buffered aqueous solution, ph7.2.
|
References:
|
Miyake, K., Shimazu, R., Kondo, J., Niki, T., Akashi, S., Ogata, H., ... & Kimoto, M. (1998). Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. The Journal of Immunology,161(3), 1348-1353. Miyake, K., Yamashita, Y., Ogata, M., Sudo, T., & Kimoto, M. (1995). RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. The Journal of Immunology, 154(7), 3333-3340. Chan, V. W., Mecklenbräuker, I., Su, I. H., Texido, G., Leitges, M., Carsetti, R., ... & Tarakhovsky, A. (1998). The molecular mechanism of B cell activation by toll-like receptor protein RP-105. The Journal of experimental medicine,188(1), 93-101. |