Anti-Mouse CD14 FITC

Catalog Number : 06212-50

Description

The Sa2-8 monoclonal antibody specifically reacts with mouse CD14, a cell surface anchored glycoprotein that is primarily expressed on macrophages and is secreted in certain conditions. CD14 associates with LPS and LBP to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The Sa2-8 antibody exhibits a weak antagonistic activate in relation to TNF alpha production and NF-kappa B activation.

Additional Information

Clone:	Sa2-8
Format:	FITC
Applications:	FC
Reactivity:	Mouse
Isotype:	Rat IgG2a, kappa
Research Interest:	Innate Immunity
Cell Type:	Monocytes and Macrophages
Preparation:	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:	Akashi, S., Saitoh, S. I., Wakabayashi, Y., Kikuchi, T., Takamura, N., Nagai, Y., ... & Miyake, K. (2003). Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2 Higher Affinity than That with MD-2 or CD14. The Journal of experimental medicine, 198(7), 1035-1042. Oliva, C., Turnbough, C. L., & Kearney, J. F. (2009). CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages. Proceedings of the National Academy of Sciences, 106(33), 13957-13962.

Availability: In stock

Size	Price	Qty
50 ug	$100.00
100 ug	$190.00
500 ug	$320.00

Additional Sa2-8 Formats

Cat.No.	Format	Starting From
06212-50	FITC	$ 100.00