Anti-Mouse CD127 (IL-7Ra) PE
The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the α subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.
The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127.
Rat IgG2a, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||B Cells, T Cells, T Regulatory Cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Sudo, T., Nishikawa, S. A. T. O. M. I., Ohno, N. O. R. I. K. O., Akiyama, N. A. O. K. O., Tamakoshi, M. A. S. A. T. A. D. A., & Yoshida, H. I. S. A. H. I. R. O. (1993). Expression and function of the interleukin 7 receptor in murine lymphocytes. Proceedings of the National Academy of Sciences, 90(19), 9125-9129.
Hashi, H., Yoshida, H., Honda, K., Fraser, S., Kubo, H., Awane, M., ... & Nishikawa, S. I. (2001). Compartmentalization of Peyer’s patch anlagen before lymphocyte entry. The Journal of Immunology, 166(6), 3702-3709.
Okuno, Y., Iwasaki, H., Huettner, C. S., Radomska, H. S., Gonzalez, D. A., Tenen, D. G., & Akashi, K. (2002). Differential regulation of the human and murine CD34 genes in hematopoietic stem cells. Proceedings of the National Academy of Sciences, 99(9), 6246-6251.