Anti-Mouse CD122 SAFIRE Purified

Grouped product items
Size	Price	Qty
100ug	$310.00
500ug	$560.00

Additional TM-beta1 Formats

Cat.No.	Format	Starting From
14312-25	SAFIRE Purified	$ 310.00

Catalog Number : 14312-25

description

The TM-beta1 monoclonal antibody specifically reacts with mouse CD122, a beta chain shared by the IL-2 and IL-15 receptors. It is expressed by B cells, T cells, and NK cells and can be used as a marker for NK-cell progenitors. CD122 forms complexes involved in immunoregulation and signal transduction. The TM-beta1 antibody is reported to block the binding of IL-2 and IL-15 to the IL-2 beta receptor.

Additional Information

Clone:	TM-beta1
Format:	SAFIRE Purified
Applications:	FC, FA
Reactivity:	Mouse
Isotype:	Rat IgG2b
Cell Type:	T Cells, NK and NKT Cells, B Cells
Application:	FC, FA
Clone:	TM-beta1
Preparation:	The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation:	Phosphate-buffered aqueous solution, ph7.2.
References:	Alleva, D. G., Kaser, S. B., Monroy, M. A., Fenton, M. J., & Beller, D. I. (1997). IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential receptor subunit utilization associated with stimulation or inhibition. The Journal of Immunology,159(6), 2941-2951. Suzuki, H., Kundig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., ... & Griesser, H. (1995). Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science, 268(5216), 1472-1476. Takeuchi, Y., Tanaka, T., Hamamura, K., Sugimoto, T., Miyasaka, M., Yagita, H., & Okumura, K. (1992). Expression and role of interleukin‐2 receptor β chain on CD4− CD8+ T cell receptor αβ+ cells. European journal of immunology,22(11), 2929-2935.