Anti-Mouse CD115 (CSF-1R) FITC
The AFS98 monoclonal antibody specifically reacts with the mouse CD115 molecule, a 150 kDa receptor for the colony stimulating factor (CSF-1) or macrophage CFS (M-CFS), expressed by some epithelial cells, monocytes, osteoclasts, and macrophages. The colony stimulating factor-1 regulates the proliferation and the differentiation of the monocytic lineage cells.
The AFS98 antibody can be used to identify myeloid lineage cells.
Rat IgG2a, kappa
|Research Interest:||Innate Immunity, Angiogenesis|
|Cell Type:||Macrophage / Monocyte|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Murayama, T., Yokode, M., Kataoka, H., Imabayashi, T., Yoshida, H., Sano, H., ... & Kita, T. (1999). Intraperitoneal administration of anti–c-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein E–deficient mice. Circulation, 99(13), 1740-1746.
Sudo, T., Nishikawa, S., Ogawa, M., Kataoka, H., Ohno, N., Izawa, A., & Hayashi, S. (1995). Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M. Oncogene, 11(12), 2469-2476.
Yoshino, M., Yamazaki, H., Yoshida, H., Niida, S., Nishikawa, S. I., Ryoke, K., ... & Hayashi, S. I. (2003). Reduction of osteoclasts in a critical embryonic period is essential for inhibition of mouse tooth eruption. Journal of Bone and Mineral Research, 18(1), 108-116.