Anti-Human TIM3 PE-Cyanine7

Grouped product items
Size	Price	Qty
25 tests	$185.00
100 tests	$450.00

Additional F38-2E2 Formats

Cat.No.	Format	Starting From
78211-80	APC	$ 130.00
78211-25	SAFIRE Purified	$ 470.00
78211-77	PE-Cyanine7	$ 185.00

Catalog Number : 78211-77

description

The F38-2E2 monoclonal antibody specifically reacts with human T cell immunoglobulin and mucin domain containing protein (TIM3), a transmembrane molecule found on monocytes, macrophages, dendritic cells, and activated T cell types such as Treg, Th1, and Th17. TIM3 can exist in soluble and membrane bound forms and the relevant ligand for the protein is Galectin-9. It plays a role in the creation of immunological tolerances, the secretion of Th1 and Th17 related cytokines, and HIV infection.

Additional Information

Clone:	F38-2E2
Format:	PE-Cyanine7
Applications:	FC
Reactivity:	Human
Isotype:	Mouse IgG1, kappa
Research Interest:	Adaptive Immunity
Cell Type:	Th1 cells, Macrophage / Monocyte, T Regulatory Cells, Th17 cells
Application:	FC
Clone:	F38-2E2
Preparation:	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:	Klibi, J., Niki, T., Riedel, A., Pioche-Durieu, C., Souquere, S., Rubinstein, E., ... & Busson, P. (2009). Blood diffusion and Th1-suppressive effects of galectin-9–containing exosomes released by Epstein-Barr virus–infected nasopharyngeal carcinoma cells. Blood, 113(9), 1957-1966. Hastings, W. D., Anderson, D. E., Kassam, N., Koguchi, K., Greenfield, E. A., Kent, S. C., ... & Kuchroo, V. K. (2009). TIM‐3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. European journal of immunology, 39(9), 2492-2501. Koguchi, K., Anderson, D. E., Yang, L., O'Connor, K. C., Kuchroo, V. K., & Hafler, D. A. (2006). Dysregulated T cell expression of TIM3 in multiple sclerosis. The Journal of experimental medicine, 203(6), 1413-1418.