Anti-Human/Mouse CD62P (P-Selectin) PE
Catalog Number : 04721-60
description
The Psel.KO2.3 monoclonal antibody specifically reacts with mouse CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as granule membrane protein 140 (GMP-140). Upon activation it is quickly transported to the plasma membrane from the alpha-granules of platelets and WEibel-Palade bodies of endothelial cells. It is essential to the functions of cell adhesion during inflammatory reactions and in the interaction of platelets with monocytes and neutrophils. The Psel.KO2.3 antibody does not block adhesion and binds to an epitope common to several species including mouse, human, and rat.
Additional Information
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Clone:
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Psel.KO2.3
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Format:
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PE
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Applications:
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FC
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Reactivity:
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Human, Mouse
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | Adaptive Immunity, Angiogenesis |
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| Application: | FC |
| Clone: | Psel.KO2.3 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Massaguer, A., Engel, P., Pérez‐del‐Pulgar, S., Bosch, J., & Pizcueta, P. (2000). Production and characterization of monoclonal antibodies against conserved epitopes of P‐selectin (CD62P). Tissue antigens, 56(2), 117-128. Kansas, G. S. (1996). Selectins and their ligands: current concepts and controversies. Blood, 88(9), 3259-3287. Bullard, D. C., Kunkel, E. J., Kubo, H., Hicks, M. J., Lorenzo, I., Doyle, N. A., ... & Beaudet, A. L. (1996). Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. The Journal of experimental medicine, 183(5), 2329-2336. |