Anti-Human/Mouse CD44 PE-Cyanine7
Additional IM7 Formats
Cat.No. | Format | Starting From |
---|---|---|
06511-60 | PE | $ 55.00 |
06511-65 | PE-Cyanine5 | $ 70.00 |
06511-70 | PerCP-Cyanine5.5 | $ 85.00 |
06511-40 | BG Violet 450 | $ 85.00 |
06511-20 | Purified | $ 130.00 |
06511-50 | FITC | $ 55.00 |
06511-87 | APC-Cyanine7 | $ 75.00 |
06511-80 | APC | $ 60.00 |
06511-77 | PE-Cyanine7 | $ 75.00 |
06511-25 | SAFIRE Purified | $ 285.00 |
description
The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.
The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice.
The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.
Additional Information
Clone:
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IM7
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Format:
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PE-Cyanine7
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Applications:
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FC
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Reactivity:
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Human, Mouse
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Isotype:
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Rat IgG2b, kappa
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Research Interest: | Adaptive Immunity, Stem Cell Research, Angiogenesis |
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Cell Type: | Macrophage / Monocyte |
Application: | FC |
Clone: | IM7 |
Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., & Trotter, J. (1982). Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics,15(3), 299-312. Lesley, J., & Trowbridge, I. S. (1982). Genetic characterization of a polymorphic murine cell-surface glycoprotein. Immunogenetics, 15(3), 313-320. Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., & Naor, D. (1999). CD44 involvement in experimental collagen-induced arthritis (CIA). Journal of autoimmunity, 13(1), 39-47. |