Anti-Human/Mouse CD44 PE-Cyanine5

Catalog Number : 06511-65

Description

The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.

The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice.

The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.

Additional Information

Clone:	IM7
Format:	PE-Cyanine5
Applications:	FC
Reactivity:	Human, Mouse
Isotype:	Rat IgG2b, kappa
Research Interest:	Adaptive Immunity, Angiogenesis, Stem Cell Research
Cell Type:	Monocytes and Macrophages
Preparation:	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:	Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., & Trotter, J. (1982). Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics,15(3), 299-312. Lesley, J., & Trowbridge, I. S. (1982). Genetic characterization of a polymorphic murine cell-surface glycoprotein. Immunogenetics, 15(3), 313-320. Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., & Naor, D. (1999). CD44 involvement in experimental collagen-induced arthritis (CIA). Journal of autoimmunity, 13(1), 39-47.

Availability: In stock

Size	Price	Qty
25 μg	$70.00
100 μg	$160.00

Additional IM7 Formats

Cat.No.	Format	Starting From
06511-60	PE	$ 55.00
06511-65	PE-Cyanine5	$ 70.00
06511-70	PerCP-Cyanine5.5	$ 85.00
06511-40	BG Violet 450	$ 80.00
06511-20	Purified	$ 130.00
06511-50	FITC	$ 55.00
06511-87	APC-Cyanine7	$ 75.00
06511-80	APC	$ 60.00
06511-77	PE-Cyanine7	$ 75.00
06511-25	SAFIRE Purified	$ 110.00