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Anti-Human/Mouse CD11b Biotin

Catalog Number : 03221-30


The M1/70 monoclonal antibody specifically reacts with the 170 kDa αM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18). Mac-1 binds to C3bi, CD54 (ICAM-1), and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood.

M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.

Additional Information

Human, Mouse
Rat IgG2b, kappa
Research Interest: Innate Immunity, Angiogenesis
Cell Type: Monocytes and Macrophages, NK and NKT Cells
Protein Cross Reactivity: Baboon, Chimpanzee, Cynomolgus, Rhesus
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Sanchez-Madrid, F., Simon, P., Thompson, S., & Springer, T. A. (1983). Mapping of antigenic and functional epitopes on the alpha-and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1.The Journal of experimental medicine158(2), 586-602.

Ault, K. A., & Springer, T. A. (1981). Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells. The Journal of Immunology126(1), 359-364.

Springer, T., Galfre, G., Secher, D. S., & Milstein, C. (1978). Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. European journal of immunology8(8), 539-551.

Availability: In stock

Size Price Qty
25 μg
100 μg
500 μg
Additional M1/70 Formats
Cat.No. Format Starting From
03221-60PE $ 60.00
03221-65PE-Cyanine5 $ 65.00
03221-70PerCP-Cyanine5.5 $ 70.00
03221-20Purified $ 90.00
03221-50FITC $ 70.00
03221-30Biotin $ 30.00
03221-87APC-Cyanine7 $ 75.00
03221-80APC $ 50.00
03221-77PE-Cyanine7 $ 70.00
03221-40BG Violet 450 $ 110.00
03221-25SAFIRE Purified $ 135.00