Anti-Human Foxp3 PE

Grouped product items
Size	Price	Qty
25 tests	$295.00
100 tests	$590.00

Additional 236A/E7 Formats

Cat.No.	Format	Starting From
83421-60	PE	$ 295.00

Catalog Number : 83421-60

description

The 236A/E7 monoclonal antibody specifically reacts with human Foxp3, also known as Forkhead Box P3, Scurfin, IPEX, and JM2. The 49-55 kDA transcription factor is the primary marker for CD4+ CD25+ regulatory T cells. Treg cells suppress the cytokine production and proliferation of other T cells and are essential in T cell mediated autoimmunity. The 236A/E7 antibody also cross reacts with cynomolgus macaque, rhesus macaque, and sooty mangabey.

Additional Information

Clone:	236A/E7
Format:	PE
Applications:	PE
Reactivity:	Human
Isotype:	Mouse IgG1, kappa
Research Interest:	Adaptive Immunity
Cell Type:	T Cells, T Regulatory Cells
Application:	PE
Clone:	236A/E7
Preparation:	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:	Roncador, G., Brown, P. J., Maestre, L., Hue, S., Martínez‐Torrecuadrada, J. L., Ling, K. L., ... & Banham, A. H. (2005). Analysis of FOXP3 protein expression in human CD4+ CD25+ regulatory T cells at the single‐cell level.European journal of immunology, 35(6), 1681-1691. Roncador, G., Garcia, J. F., Maestre, L., Lucas, E., Menarguez, J., Ohshima, K., ... & Piris, M. A. (2005). FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma. Leukemia, 19(12), 2247-2253. Wolf, D., Wolf, A. M., Rumpold, H., Fiegl, H., Zeimet, A. G., Muller-Holzner, E., ... & Marth, C. (2005). The expression of the regulatory T cell–specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clinical Cancer Research, 11(23), 8326-8331.