Anti-Human Foxp3 PE
Catalog Number : 83411-60
description
The PCH101 monoclonal antibody specifically reacts with human Foxp3, also known as Forkhead Box P3, Scurfin, IPEX, and JM2. The 49-55 kDA transcription factor is the primary marker for CD4+ CD25+ regulatory T cells. Treg cells suppress the cytokine production and proliferation of other T cells and are essential in T cell mediated autoimmunity. The PCH101 antibody also cross reacts with cynomolgus macaque, rhesus macaque, and chimpanzee.
Additional Information
|
Clone:
|
PCH101
|
|
Format:
|
PE
|
|
Applications:
|
PE
|
|
Reactivity:
|
Human
|
|
Isotype:
|
Rat IgG2a, kappa
|
| Research Interest: | Adaptive Immunity |
|---|---|
| Cell Type: | T Cells, T Regulatory Cells |
| Application: | PE |
| Clone: | PCH101 |
|
Preparation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
Allan, S. E., Crome, S. Q., Crellin, N. K., Passerini, L., Steiner, T. S., Bacchetta, R., ... & Levings, M. K. (2007). Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. International immunology, 19(4), 345-354. Tran, D. Q., Ramsey, H., & Shevach, E. M. (2007). Induction of FOXP3 expression in naive human CD4+ FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype. Blood, 110(8), 2983-2990. Pillai, V., & Karandikar, N. J. (2008). Attack on the clones? Human FOXP3 detection by PCH101, 236A/E7, 206D, and 259D reveals 259D as the outlier with lower sensitivity. Blood, 111(1), 463-464. |