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Anti-Human Fc epsilon Receptor I alpha (FceR1) FITC



Catalog Number : 84111-50

Description

The AER-37 (CRA1) antibody binds to the FC epsilon receptor I alpha subunit (FceR1a), a 50 kDA transmembrane protein. It is part of a tetrameric receptor complex composed from one alpha subunit, one beta subunit, and two gamma subunits. The FceR1a binds and is upregulated by the presence of IgE. It plays a role in prompting the allergic reactions mediated by IgE.

Additional Information

Clone:
AER-37 (CRA1)
Format:
FITC
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG2b, kappa
Research Interest: Innate Immunity
Cell Type: Monocytes and Macrophages, Dendritic Cells
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Maurer, D., Fiebiger, E., Ebner, C., Reininger, B., Fischer, G. F., Wichlas, S., ... & Stingl, G. (1996). Peripheral blood dendritic cells express FceRI as a complex composed of FceRIa-and FceRIy-chains and can use this receptor for IgE-mediated allergen presentation. J Immunol157, 607-616.

Yamaguchi, M., Sayama, K., Yano, K., Lantz, C. S., Noben-Trauth, N., Ra, C., ... & Galli, S. J. (1999). IgE enhances Fcε receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fcε receptor I expression and mediator release. The Journal of Immunology,162(9), 5455-5465.

Ra, C., Kuromitsu, S., Hirose, T., Yasuda, S., Furuichi, K., & Okumura, K. (1993). Soluble human high-affinity receptor for IgE abrogates the IgE-mediated allergic reaction. International immunology5(1), 47-54.


Availability: In stock

Size Price Qty
25 tests
$160.00
100 tests
$310.00
Additional AER-37 (CRA1) Formats
Cat.No. Format Starting From
84111-50FITC $ 160.00