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Anti-Human CD80 (B7-1) PE-Cyanine5



Catalog Number : 02911-65

Description

The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

Additional Information

Clone:
2D10.4
Format:
PE-Cyanine5
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest: Adaptive Immunity
Cell Type: B Cells, T Cells
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.

Cognasse, F., Hamzeh‐Cognasse, H., Lafarge, S., Chavarin, P., Pozzetto, B., Richard, Y., & Garraud, O. (2008). Identification of two subpopulations of purified human blood B cells, CD27− CD23+ and CD27high CD80+, that strongly express cell surface Toll‐like receptor 9 and secrete high levels of interleukin‐6. Immunology125(3), 430-437.

Bashuda, H., Kimikawa, M., Seino, K., Kato, Y., Ono, F., Shimizu, A., ... & Okumura, K. (2005). Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. Journal of Clinical Investigation115(7), 1896-1902.


Availability: In stock

Size Price Qty
25 tests
$145.00
100 tests
$315.00
Additional 2D10.4 Formats
Cat.No. Format Starting From
02911-50FITC $ 90.00
02911-60PE $ 100.00
02911-25SAFIRE Purified $ 120.00
02911-30Biotin $ 200.00
02911-65PE-Cyanine5 $ 145.00
02911-20Purified $ 110.00