Anti-Human CD80 (B7-1) PE-Cyanine5

Grouped product items
Size	Price	Qty
100 tests	$540.00

Additional 2D10.4 Formats

Cat.No.	Format	Starting From
02911-50	FITC	$ 110.00
02911-60	PE	$ 100.00
02911-25	SAFIRE Purified	$ 600.00
02911-30	Biotin	$ 350.00
02911-65	PE-Cyanine5	$ 540.00
02911-20	Purified	$ 185.00

Catalog Number : 02911-65

description

The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

Additional Information

Clone:	2D10.4
Format:	PE-Cyanine5
Applications:	FC
Reactivity:	Human
Isotype:	Mouse IgG1, kappa
Research Interest:	Adaptive Immunity
Cell Type:	B Cells, T Cells
Application:	FC
Clone:	2D10.4
Preparation:	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:	Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998. Cognasse, F., Hamzeh‐Cognasse, H., Lafarge, S., Chavarin, P., Pozzetto, B., Richard, Y., & Garraud, O. (2008). Identification of two subpopulations of purified human blood B cells, CD27− CD23+ and CD27high CD80+, that strongly express cell surface Toll‐like receptor 9 and secrete high levels of interleukin‐6. Immunology, 125(3), 430-437. Bashuda, H., Kimikawa, M., Seino, K., Kato, Y., Ono, F., Shimizu, A., ... & Okumura, K. (2005). Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. Journal of Clinical Investigation, 115(7), 1896-1902.