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Anti-Human CD49d FITC



Catalog Number : 11511-50

Description

The 9F10 monoclonal antibody specifically reacts with human CD49d, the 150 kDA alpha 4 integrin chain. The molecule forms the heterodimer called VLA-4 with integrin beta 1 and another heterodimer with integrin beta 7 that binds fibronectin, VCAM-1, and MadCAM-1. CD49d is expressed on monocytes, lymphocytes, thymocytes, NK cells, B cells, and T cells. It is involved in hematopoietic stem cell differentiation, cell migration, and cell activation. Its absence on Foxp3+ cells make it a useful marker to isolate Treg cell populations.

Additional Information

Clone:
9F10
Format:
FITC
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest: Adaptive Immunity, Angiogenesis
Cell Type: T Cells, B Cells, Monocytes and Macrophages, Dendritic Cells
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Schlossman, S. F. (1995). Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

Kleinewietfeld, M., Starke, M., Di Mitri, D., Borsellino, G., Battistini, L., Rötzschke, O., & Falk, K. (2009). CD49d provides access to “untouched” human Foxp3+ Treg free of contaminating effector cells. Blood113(4), 827-836.

Hemler, M. E. (1990). VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annual review of immunology8(1), 365-400.


Availability: In stock

Size Price Qty
25 tests
$125.00
100 tests
$280.00
Additional 9F10 Formats
Cat.No. Format Starting From
11511-80APC $ 150.00
11511-50FITC $ 125.00
11511-60PE $ 110.00
11511-20Purified $ 50.00