Anti-Human CD4 FITC
Catalog Number : 06131-50
The SK3 monoclonal antibody specifically binds to human CD4, a single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation, together with the MHC class II. The SK3 antibody inhibits HIV binding to CD4+ cells. It and the RPA-T4 antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
Mouse IgG1, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||T Cells, T Regulatory Cells, Macrophage / Monocyte|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Louache, F., Debili, N., Marandin, A., Coulombel, L., & Vainchenker, W. (1994). Expression of CD4 by human hematopoietic progenitors [see comments]. Blood, 84(10), 3344-3355. Rand, T. H., Cruikshank, W. W., Center, D. M., & Weller, P. F. (1991). CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration. Journal of experimental medicine, 173(6), 1521-1528. Gougeon, M. L., Lecoeur, H., Dulioust, A., Enouf, M. G., Crouvoiser, M., Goujard, C., ... & Montagnier, L. (1996). Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. The Journal of Immunology, 156(9), 3509-3520.