Anti-Human CD4 Purified
Additional RPA-T4 Formats
Cat.No. | Format | Starting From |
---|---|---|
06121-20 | Purified | $ 65.00 |
06121-60 | PE | $ 50.00 |
06121-77 | PE-Cyanine7 | $ 115.00 |
06121-40 | BG Violet 450 | $ 85.00 |
06121-50 | FITC | $ 40.00 |
06121-87 | APC-Cyanine7 | $ 115.00 |
06121-80 | APC | $ 70.00 |
06121-70 | PerCP-Cyanine5.5 | $ 90.00 |
description
The RPA-T4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation, together with the MHC class II.
The RPA-T4 antibody is capable of blocking HIV binding and inhibiting syncytium formation, by binding to the D1 domain of the CD4 antigen. The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
Additional Information
Clone:
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RPA-T4
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Format:
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Purified
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Applications:
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FC, FA, IHC, IP
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Reactivity:
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Human
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Isotype:
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Mouse IgG1, kappa
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Research Interest: | Adaptive Immunity |
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Cell Type: | Th17 cells, Macrophage / Monocyte, T Cells |
Application: | FC, FA, IHC, IP |
Clone: | RPA-T4 |
Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York |