Anti-Human CD3 SAFIRE Purified
Additional UCHT1 Formats
|05131-25||SAFIRE Purified||$ 150.00|
|05131-40||BG Violet 450||$ 85.00|
|05131-45||BG Violet 500||$ 110.00|
The UCHT1 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3ε. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
FC, FA, IHC, IF, IP, WB
Mouse IgG1, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||Th17 cells, NK and NKT Cells, T Cells, T Regulatory Cells|
|Application:||FC, FA, IHC, IF, IP, WB|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Phosphate-buffered aqueous solution, ph7.2.
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
McMichael, A. J. (1987). Leucocyte typing III. Oxford University Press, Oxford. Norton AJ, Isaacson PG (1985)
Beverley, P. C., & Callard, R. E. (1981). Distinctive functional characteristics of human T lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. European journal of immunology, 11(4), 329-334.